2-(3-Fluoropiperidin-1-yl)ethan-1-amine → HCID 59077708, compound

HRID 1359868Notes

Reaction equation

HRID 1359868 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:23]\[C:24]1[NH:28][C:27]([CH3:29])=[C:26]([CH2:30][C:31](O)=[O:32])[C:25]=1[CH3:34])(=[O:12])=[O:11].[F:35][CH:36]1[CH2:41][CH2:40][CH2:39][N:38]([CH2:42][CH2:43][NH2:44])[CH2:37]1>>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:23]\[C:24]1[NH:28][C:27]([CH3:29])=[C:26]([CH2:30][C:31]([NH:44][CH2:43][CH2:42][N:38]2[CH2:39][CH2:40][CH2:41][CH:36]([F:35])[CH2:37]2)=[O:32])[C:25]=1[CH3:34])(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 181797472-(3-Fluoropiperidin-1-yl)ethan-1-amineHCID 59077497HCID 59077497, compound

Product 1

HCID 59077708HCID 59077708, compound

Procedure

{5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrol-3-yl}-acetic acid was coupled with 2-(3-fluoro-piperidin-1-yl)-ethylamine to give the titled compound.

Sources & evidence

ORD record
ord-75d30350afbb42ef96c18e089f49ca61
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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