HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18179746, compound → HCID 59077714, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18179746 | HCID 18179746 | — |
| Reactant | HCID 18179956 | HCID 18179956 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 59077714 | HCID 59077714 | 46% |
Reaction Steps
5-[2-(2-Morpholin-4-yl-ethoxy)-phenylmethanesulfonyl]-1,3-dihydro-indol-2-one (39 mg, 0.094 mmol) was condensed with 4-[(cyclopropyl-methyl-amino)-methyl]-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (21 mg, 0.1 mmol) and piperidine (1 drop) in ethanol (1.5 mL) at rt for 48 hours. The solvent was removed and the residue was purified on a silica gel column to give 26 mg (46%) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06599902B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-065d2678e71d4bfda069d4e7d444821b |
| Source note | uspto-grants-2003_07 |