Acetic Acid → HCID 59780174, compound

HRID 1359902Notes

Reaction equation

HRID 1359902 reaction equation
[OH:1][CH:2]([CH:21]=[CH2:22])[CH:3]([NH:8][C:9]([C:11]1[C:12]([C:17]([F:20])([F:19])[F:18])=[N:13][N:14]([CH3:16])[CH:15]=1)=[O:10])[C:4](=[O:7])[NH:5][CH3:6].[C:23](O)(=[O:25])[CH3:24].CN(C1C=CC=CN=1)C>C(Cl)Cl>[C:23]([O:1][CH:2]([CH:3]([C:4](=[O:7])[NH:5][CH3:6])[NH:8][C:9]([C:11]1[C:12]([C:17]([F:20])([F:19])[F:18])=[N:13][N:14]([CH3:16])[CH:15]=1)=[O:10])[CH:21]=[CH2:22])(=[O:25])[CH3:24]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 218852-DimethylaminopyridineHCID 59780173HCID 59780173, compound

Product 1

HCID 59780174HCID 59780174, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

134 mg (0.42 mmol) of N-(2-hydroxy-1-methylcarbamoylbut-3-enyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, 28 mg (0.46 mmol) of acetic acid and 20 mg (0.17 mmol) of dimethylaminopyridine were dissolved in CH2Cl2. At 0° C., 88 mg (0.46 mmol) of 1-(3-dimethylaminopropyl)-3-(ethylcarbodiimide) hydrochloride were added. After 16 h of stirring at RT, the reaction solution was washed and the solvent was removed. This gave 0.10 g (66% of theory) of the title compound as a colorless powder (M+(m/z)=362).

Workup

  1. washthe reaction solution was washed
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-d94e516bfa604dce9c64081db90e7423
Source dataset
uspto-grants-2011_02
Patent number
US07879761B2

Reaction notes

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