Dimethyl Sulfoxide → HCID 86628350, compound

HRID 1359910Notes

Reaction equation

CS(C)=O.[CH3:5][CH2:6][C@@H:7]([C@H:9]([NH:92][C:93]([C@@H:95]([NH:97][C:98]([CH2:100][NH:101][C:102]([C@@H:104]([NH:112][C:113]([C@@H:115]([NH:120][C:121]([C@@H:123]([NH:128][C:129]([C@@H:131]([NH:134][C:135]([C@@H:137]([NH:140][C:141]([C@@H:143]([NH:150][C:151]([C@@H:153]([NH:157][C:158]([C@@H:160]([NH:165][C:166]([C@@H:168]([NH:176][C:177]([C@@H:179]([NH:184][C:185]([C@@H:187]([NH:189][C:190]([C@@H:192]([NH:197][C:198]([C@@H:200]([NH:208][C:209]([C@@H:211]([NH:217][C:218]([C@@H:220]([NH:224][C:225]([C@@H:227]([NH:229][C:230]([C@H:232]1[NH:256][C:254](=[O:255])[C@H:253]([C@H:257]([OH:259])[CH3:258])[NH:252][C:250](=[O:251])[C@H:249]([CH3:260])[NH:248][C:246](=[O:247])[C@H:245]([C@H:261]([OH:263])[CH3:262])[NH:244][C:242](=[O:243])[C@@H:241]([CH2:264][C:265]([NH2:267])=[O:266])[NH:240][C:238](=[O:239])[C@@H:237]([NH:268][C:269]([C@@H:271]([NH2:277])[CH2:272][CH2:273][CH2:274][CH2:275][NH2:276])=[O:270])[CH2:236][S:235][S:234][CH2:233]1)=[O:231])[CH3:228])=[O:226])[C@H:221]([OH:223])[CH3:222])=[O:219])[CH2:212][CH2:213][C:214]([NH2:216])=[O:215])=[O:210])[CH2:201][CH2:202][CH2:203][NH:204][C:205]([NH2:207])=[NH:206])=[O:199])[CH2:193][CH:194]([CH3:196])[CH3:195])=[O:191])[CH3:188])=[O:186])[CH2:180][C:181]([NH2:183])=[O:182])=[O:178])[CH2:169][C:170]1[CH:171]=[CH:172][CH:173]=[CH:174][CH:175]=1)=[O:167])[CH2:161][CH:162]([CH3:164])[CH3:163])=[O:159])[CH:154]([CH3:156])[CH3:155])=[O:152])[CH2:144][C:145]1[NH:149][CH:148]=[N:147][CH:146]=1)=[O:142])[CH2:138][OH:139])=[O:136])[CH2:132][OH:133])=[O:130])[CH2:124][C:125]([NH2:127])=[O:126])=[O:122])[CH2:116][C:117]([NH2:119])=[O:118])=[O:114])[CH2:105][C:106]1[CH:107]=[CH:108][CH:109]=[CH:110][CH:111]=1)=[O:103])=[O:99])[CH3:96])=[O:94])[C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:24]([NH:26][C@H:27]([C:30]([NH:32][C@H:33]([C:37]([NH:39][C@H:40]([C:45]([NH:47][C@H:48]([C:52]([NH:54][CH2:55][C:56]([NH:58][C@H:59]([C:62]([NH:64][C@H:65]([C:70]([NH:72][C@H:73]([C:77]([NH:79][C@H:80]([C:89]([OH:91])=[O:90])[CH2:81][C:82]1[CH:83]=[CH:84][C:85]([OH:88])=[CH:86][CH:87]=1)=[O:78])[C@H:74]([OH:76])[CH3:75])=[O:71])[CH2:66][C:67]([NH2:69])=[O:68])=[O:63])[CH2:60][OH:61])=[O:57])=[O:53])[CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:41][C:42]([NH2:44])=[O:43])=[O:38])[C@H:34]([OH:36])[CH3:35])=[O:31])[CH2:28][OH:29])=[O:25])[CH2:22][OH:23])=[O:19])[CH2:14][CH:15]([CH3:17])[CH3:16])=[O:11])[CH3:8].[CH3:278][CH:279]([CH2:281][CH:282]([N:294]([CH3:296])[CH3:295])[C:283]1([C:287]2[CH:288]=[CH:289][C:290]([Cl:293])=[CH:291][CH:292]=2)[CH2:286][CH2:285][CH2:284]1)[CH3:280]>O>[CH3:5][CH2:6][C@@H:7]([C@H:9]([NH:92][C:93]([C@@H:95]([NH:97][C:98]([CH2:100][NH:101][C:102]([C@@H:104]([NH:112][C:113]([C@@H:115]([NH:120][C:121]([C@@H:123]([NH:128][C:129]([C@@H:131]([NH:134][C:135]([C@@H:137]([NH:140][C:141]([C@@H:143]([NH:150][C:151]([C@@H:153]([NH:157][C:158]([C@@H:160]([NH:165][C:166]([C@@H:168]([NH:176][C:177]([C@@H:179]([NH:184][C:185]([C@@H:187]([NH:189][C:190]([C@@H:192]([NH:197][C:198]([C@@H:200]([NH:208][C:209]([C@@H:211]([NH:217][C:218]([C@@H:220]([NH:224][C:225]([C@@H:227]([NH:229][C:230]([C@H:232]1[NH:256][C:254](=[O:255])[C@H:253]([C@H:257]([OH:259])[CH3:258])[NH:252][C:250](=[O:251])[C@H:249]([CH3:260])[NH:248][C:246](=[O:247])[C@H:245]([C@H:261]([OH:263])[CH3:262])[NH:244][C:242](=[O:243])[C@@H:241]([CH2:264][C:265]([NH2:267])=[O:266])[NH:240][C:238](=[O:239])[C@@H:237]([NH:268][C:269]([C@@H:271]([NH2:277])[CH2:272][CH2:273][CH2:274][CH2:275][NH2:276])=[O:270])[CH2:236][S:235][S:234][CH2:233]1)=[O:231])[CH3:228])=[O:226])[C@H:221]([OH:223])[CH3:222])=[O:219])[CH2:212][CH2:213][C:214]([NH2:216])=[O:215])=[O:210])[CH2:201][CH2:202][CH2:203][NH:204][C:205]([NH2:207])=[NH:206])=[O:199])[CH2:193][CH:194]([CH3:196])[CH3:195])=[O:191])[CH3:188])=[O:186])[CH2:180][C:181]([NH2:183])=[O:182])=[O:178])[CH2:169][C:170]1[CH:171]=[CH:172][CH:173]=[CH:174][CH:175]=1)=[O:167])[CH2:161][CH:162]([CH3:164])[CH3:163])=[O:159])[CH:154]([CH3:156])[CH3:155])=[O:152])[CH2:144][C:145]1[NH:149][CH:148]=[N:147][CH:146]=1)=[O:142])[CH2:138][OH:139])=[O:136])[CH2:132][OH:133])=[O:130])[CH2:124][C:125]([NH2:127])=[O:126])=[O:122])[CH2:116][C:117]([NH2:119])=[O:118])=[O:114])[CH2:105][C:106]1[CH:111]=[CH:110][CH:109]=[CH:108][CH:107]=1)=[O:103])=[O:99])[CH3:96])=[O:94])[C:10]([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:24]([NH:26][C@H:27]([C:30]([NH:32][C@H:33]([C:37]([NH:39][C@H:40]([C:45]([NH:47][C@H:48]([C:52]([NH:54][CH2:55][C:56]([NH:58][C@H:59]([C:62]([NH:64][C@H:65]([C:70]([NH:72][C@H:73]([C:77]([NH:79][C@H:80]([C:89]([OH:91])=[O:90])[CH2:81][C:82]1[CH:87]=[CH:86][C:85]([OH:88])=[CH:84][CH:83]=1)=[O:78])[C@H:74]([OH:76])[CH3:75])=[O:71])[CH2:66][C:67]([NH2:69])=[O:68])=[O:63])[CH2:60][OH:61])=[O:57])=[O:53])[CH:49]([CH3:50])[CH3:51])=[O:46])[CH2:41][C:42]([NH2:44])=[O:43])=[O:38])[C@H:34]([OH:36])[CH3:35])=[O:31])[CH2:28][OH:29])=[O:25])[CH2:22][OH:23])=[O:19])[CH2:14][CH:15]([CH3:17])[CH3:16])=[O:11])[CH3:8].[CH3:280][CH:279]([CH2:281][CH:282]([N:294]([CH3:295])[CH3:296])[C:283]1([C:287]2[CH:288]=[CH:289][C:290]([Cl:293])=[CH:291][CH:292]=2)[CH2:284][CH2:285][CH2:286]1)[CH3:278]

Participants

Procedure

In-bred DIO prone rats were obtained from Charles Rivers Labs. These rats were developed from a line of Crl:CD® (SD)BR rats that are prone to become obese on a diet relatively high in fat and energy (Levin, 1997). The rats were housed individually in shoebox cages at 22° C. in a 12/12-hour light dark cycle. Rats were maintained ad-libitum on a moderately high fat diet (32% kcal from fat; Research Diets D1226B) for 6 weeks prior to drug treatment. At the end of the fattening period they typically have a mean body weight of 500 g. Rats were then divided into treatment groups and implanted with two subcutaneous mini-pumps (Durect Corp). One pump contained either vehicle (50% DMSO in water) or amylin (100 μg/kg/day) while the other pump contained either sterile water or sibutramine (3 mg/kg/day).

Workup

customwere housed individually in shoebox cages at 22° C. in a 12
custom12-hour light dark cycle
temperatureRats were maintained ad-libitum on a moderately high fat diet (32% kcal from fat; Research Diets D1226B) for 6 weeks

Sources & evidence

ORD record: ord-923863bfda8040909ffa121b981db0a5
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879794B2

Reaction notes

Loading…

Reaction equation

Participants

Reactant 3

Product 1

Reagents, catalysts & solvents 1

Procedure

Workup

Sources & evidence

Reaction notes