3-Pyrroline → (p-bromobenzyl)diethyl amine

HRID 1359950Notes

Reaction equation

HRID 1359950 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6]CO)=[CH:4][CH:3]=1.[NH:11]1[CH2:15][CH:14]=[CH:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:11]([CH2:15][CH3:14])[CH2:12][CH3:13])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 660593-PyrrolineHCID 728512-(4-Bromophenyl)ethanol

Product 1

HCID 10999178(p-bromobenzyl)diethyl amine

Procedure

The procedure of step (i) of Reference Example 2 was repeated, except that 4-bromophenethyl alcohol was used instead of 4-bromobenzylalcohol and various amines were used instead of 2,5-dihydro-1H-pyrrole. The following compounds thus synthesized were used in the Examples.

Workup

  1. customThe following compounds thus synthesized

Sources & evidence

ORD record
ord-b5df6ee634354884a30c57ccfcadd991
Source dataset
uspto-grants-2011_02
Patent number
US07879808B2

Reaction notes

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