反应详情

Under ice-cooling, 20 ml of 4 M hydrochloric acid/ethyl acetate was added to 5.330 g (12.95 mmol) of the Boc-aminopropanol-ketoprofen obtained above, followed by stirring under ice-cooling for 15 minutes and at room temperature for 2 hours. After confirming disappearance of Boc-aminopropanol-ketoprofen by TLC, the solvent was evaporated under reduced pressure, and the residue was subjected twice to decantation with diethyl ether. Thereafter, the residue was dried under reduced pressure to quantitatively give the titled substance at a yield of 4.569 g. The structure was identified by 1H-NMR (CDCl3).

1. temperatureUnder ice-cooling
2. customobtained above,
3. customthe solvent was evaporated under reduced pressure
4. customThereafter, the residue was dried under reduced pressure
5. customto quantitatively give the titled substance at a yield of 4.569 g