反应详情

In 1 ml of dichloromethane, 684 mg (1.76 mmol) of the Boc-aminopropanol-naproxen obtained above was dissolved, and 2 ml of 4 M hydrochloric acid/ethyl acetate was added thereto under ice-cooling, followed by stirring under ice-cooling for 20 minutes and at room temperature for 1 hour. After confirming disappearance of Boc-aminopropanol-naproxen by TLC, and diethyl ether was added thereto, followed by decantation three times. Thereafter, the residue was dried under reduced pressure to quantitatively give the titled substance at a yield of 564 mg. The structure was identified by 1H-NMR (CDCl3).

1. dissolutionabove was dissolved
2. temperatureunder ice-cooling
3. additionwas added
4. customThereafter, the residue was dried under reduced pressure
5. customto quantitatively give the titled substance at a yield of 564 mg