Ibuprofen, (+-)- → HCID 86623030, compound

Participants

Reaction Steps

In 2 ml of dichloromethane, 352 mg (2 mmol) of Boc-aminopropanol and 412 g (2 mmol) of ibuprofen (manufactured by Wako Pure Chemical Industries) were dissolved, and 48 mg (0.4 mmol) of DMAP and 423 g (2.2 mmol) of WSCI.HCl/2 ml dichloromethane were added thereto in this order under ice-cooling. After returning to room temperature and stirring overnight, and ethyl acetate was added thereto, followed by separation by washing with 5% citric acid twice, water, 5% sodium hydrogen carbonate twice, water and saturated brine consecutively. After dehydration drying with sodium sulfate, ethyl acetate was evaporated under reduced pressure to give 665 mg of the titled compound (yield 91%). The structure was identified by 1H-NMR (CDCl3).

Provenance & Evidence