反应详情

In 1 ml of dichloromethane, 421.5 mg (0.948 mmol) of the Boc-aminopropanol-etodolac obtained above was dissolved, and 3 ml of 4 M hydrochloric acid/ethyl acetate was added thereto under ice-cooling, followed by stirring for 3 hours. Diethyl ether and hexane were added thereto for precipitation, and the precipitate was dried under reduced pressure. The precipitate was purified by silica gel column chromatography to give 197.6 mg (55%) of the titled compound. The structure was identified by 1H-NMR.

1. dissolutionabove was dissolved
2. temperatureunder ice-cooling
3. customfor precipitation
4. customthe precipitate was dried under reduced pressure
5. customThe precipitate was purified by silica gel column chromatography