Diethyl Ether → HCID 86623044, compound

HRID 1359991Notes

Reaction equation

HRID 1359991 reaction equation
C([C:8]([NH2:12])([OH:11])[CH2:9][CH3:10])(OC(C)(C)C)=O.[CH3:13][C:14]([NH:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][C:24]([OH:26])=[O:25])=[CH:21][CH:22]=1)=[O:15].[ClH:27].C(OCC)(=O)C.C(OCC)C>ClCCl>[NH2:12][CH:8]([OH:11])[CH2:9][CH3:10].[CH3:13][C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24]([OH:26])=[O:25])=[CH:19][CH:18]=1)=[O:15].[ClH:27]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 86623043Boc-aminopropanol actarit

Product 1

HCID 86623044HCID 86623044, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 2 ml of dichloromethane, 201.3 mg (0.574 mmol) of the Boc-aminopropanol-actarit obtained above was dissolved, and 3 ml of 4 M hydrochloric acid/ethyl acetate was added thereto under ice-cooling, followed by stirring for 3 hours. Diethyl ether was added thereto for precipitation, and the precipitate was washed twice with diethyl ether and then dried under reduced pressure to give 161.3 mg (98%) of the titled compound. The structure was identified by 1H-NMR.

Workup

  1. dissolutionabove was dissolved
  2. temperatureunder ice-cooling
  3. customfor precipitation
  4. washthe precipitate was washed twice with diethyl ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-9b57893d72464911b93319fc2eb66ecd
Source dataset
uspto-grants-2011_02
Patent number
US07879817B2

Reaction notes

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