Hexane → HCID 86623050, compound

HRID 1359997Notes

Reaction equation

HRID 1359997 reaction equation
C([C:8]([NH2:13])(O)[CH:9]([OH:11])[CH3:10])(OC(C)(C)C)=O.[OH:14][C:15]([CH:17]([C:19]1[CH:32]=[CH:31][CH:30]=[C:21]([C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:23])[CH:20]=1)[CH3:18])=[O:16].[ClH:33].C(OCC)(=O)C.CCCCCC>ClCCl>[NH2:13][CH2:8][CH:9]([OH:11])[CH2:10][OH:14].[ClH:33].[OH:16][C:15]([CH:17]([C:19]1[CH:32]=[CH:31][CH:30]=[C:21]([C:22]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[O:23])[CH:20]=1)[CH3:18])=[O:14]

Participants

5

Reactant 3

HCID 8058HexaneHCID 21866389Hydrogen chloride-ethyl acetateHCID 86623052HCID 86623052, compound

Product 1

HCID 86623050HCID 86623050, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The Boc-amino-1,2-propanediol-ketoprofen (1.76 mmol) obtained above was dissolved in dichloromethane (1 ml), and under ice-cooling, 4 N hydrochloric acid/ethyl acetate (4 ml) was added thereto, followed by stirring for 3 hours. Hexane was added to the reaction solution, and the thus formed white precipitate was dried under reduced pressure to give the titled compound (1.029 g, yield 97%). The structure was identified by 1H-NMR (CDCl3).

Workup

  1. temperatureunder ice-cooling
  2. customthe thus formed white precipitate was dried under reduced pressure

Sources & evidence

ORD record
ord-1a9279d635e6489baff3648ec455bcf2
Source dataset
uspto-grants-2011_02
Patent number
US07879817B2

Reaction notes

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