Diethyl Ether → HCID 131728634, compound

Participants

Reaction Steps

To 361 mg (0.37 mmol) of the Boc-glycine-tris(hydroxymethyl)aminomethane-ketoprofen obtained above, 2 ml of 4 M hydrochloric acid/ethyl acetate was added under ice-cooling and stirred at room temperature for 2 hours. After confirming disappearance of Boc-glycine-tris(hydroxymethyl)aminomethane-ketoprofen by TLC, diethyl ether and hexane were added thereto for decantation. Thereafter, the precipitate was dried under reduced pressure to give the titled compound quantitatively with the yield of 336 mg. The structure was identified by 1H-NMR (CDCl3).

Provenance & Evidence