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HRID136

反应详情

EQUATION

反应方程式

HRID 136 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NC1CNC1
HCID1519405

tert-Butyl azetidin-3-ylcarbamate

C8H16N2O2

结构：COc1cc(Br)ccn1
HCID14062309

4-Bromo-2-methoxypyridine

C6H6BrNO

PRODUCTS

生成物

1
结构：COc1cc(N2CC(NC(=O)OC(C)(C)C)C2)ccn1
HCID118055029

未命名化合物

收率 100.28%

AUXILIARIES

试剂、催化剂与溶剂

4
结构：CC(C)(C)[O-].[Na+]
试剂HCID23676156

Sodium t-butoxide

C4H9NaO

结构：c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1
催化剂HCID634876

2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl

C44H32P2

结构：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]
催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

CONDITIONS

反应条件

温度
70 °C

PROCEDURE

实验过程

A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated. The crude was used without further purification in the next step, EN01762-02.