HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+/-)-4-[1-(6-Methoxypyridin-2-yl)-2,2-dipyridin-3-ylethyl]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 2,2'-Oxybisacetaldehyde | HCID 81958 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 1-(6-Methoxypyridin-2-yl)-2,2-dipyridin-3-ylethanamine | HCID 57425759 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (+/-)-4-[1-(6-Methoxypyridin-2-yl)-2,2-dipyridin-3-ylethyl]morpholine | HCID 59706156 | — |
Reaction Steps
To a solution of 1-(6-methoxypyridin-2-yl)-2,2-dipyridin-3-ylethanamine (75 mg, 0.25 mmole) in CH3CN (1 mL) was added a solution of 2,2′-oxydiacetaldehyde in H2O (1.47 mL, 0.5 M, 0.73 mmole). After 10 minutes NaBH3CN (92 mg, 1.47 mmole) was added. After 2 hr 1N HCl (2 mL) was added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879839B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-07208786bb034bc78351ff260ad57854 |
| Source note | uspto-grants-2011_02 |