Hydrochloric Acid → HCID 57425774, compound

Participants

Reaction Conditions

Reaction Steps

N-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-2-methylpropane-2-sulfinamide (Diastereomer B, 1.567 g, 3.87 mmol) was dissolved in CH3OH (15 mL) and the solution was cooled to 0° C. HCl (4 M solution in dioxane, 2.905 mL, 11.62 mmol) was added drop-wise. The reaction was allowed to warm to RT and was stirred for 7 hr. The reaction was diluted with H2O and the pH was adjusted to pH=7 using saturated aqueous NaHCO3. The product was extracted with ethyl acetate (3×75 mL) followed by isobutanol (6×50 mL). The combined organics were dried over Na2SO4, filtered and concentrated in vacuo to afford 3-(1-amino-2,2-dipyridin-3-ylethyl)benzonitrile as a foamy light yellow solid.

Provenance & Evidence