Methanol → HCID 66781643, compound

HRID 1360144Notes

Reaction equation

HRID 1360144 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH3:18])[CH2:14][O:13][CH2:12][C:11]3=[CH:15][N:16]=[CH:17][N:10]23)=[CH:5][CH:4]=1.C[Si](I)(C)C.CO>C(#N)C>[CH3:18][C:9]1([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[CH2:14][O:13][CH2:12][C:11]2=[CH:15][N:16]=[CH:17][N:10]12

Participants

5

Reactant 3

HCID 887MethanolHCID 85247Trimethylsilyl iodideHCID 66781853HCID 66781853, compound

Product 1

HCID 66781643HCID 66781643, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 3.6 mmol of 5-(4-methoxyphenyl)-5-methyl-5,6-dihydro-8H-imidazo[5,1-c][1,4]-oxazine and 10 ml of trimethylsilyl iodide in 40 ml of acetonitrile is heated to reflux for 24 hours. 10 ml of methanol are cautiously added and heating to reflux is continued for 30 minutes. The reaction mixture is evaporated. The title compound is identified from the residue on the basis of the Rf by flash chromatography (SiO2 60F).

Workup

  1. temperatureis heated
  2. temperatureto reflux for 24 hours
  3. temperatureheating
  4. temperatureto reflux
  5. customThe reaction mixture is evaporated

Sources & evidence

ORD record
ord-e16d7b9c892244849d0c20531921e65d
Source dataset
uspto-grants-2011_02
Patent number
US07879847B2

Reaction notes

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