Potassium tert-butoxide → HCID 66781699, compound

HRID 1360150Notes

Reaction equation

HRID 1360150 reaction equation
CC(C)([O-])C.[K+].Cl[CH2:8][C:9]([NH:11][C:12]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)([CH3:15])[CH2:13][OH:14])=[O:10]>C(O)(CC)(C)C.CO.O>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([C:12]2([CH3:15])[NH:11][C:9](=[O:10])[CH2:8][O:14][CH2:13]2)=[CH:17][CH:18]=1

Participants

6

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 66781769HCID 66781769, compound

Product 1

HCID 66781699HCID 66781699, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 64052-Methyl-2-butanolSolvent

Procedure

A solution of 129.1 mmol of potassium tert-butoxide in 100 ml of tert-amyl alcohol is mixed at room temperature with 51.6 mmol of 2-chloro-N-[2-hydroxy-1-(4-methoxyphenyl)-1-methyl-ethyl]acetamide and stirred for 3 hours. The reaction mixture is diluted with 50 ml of methanol and 3 ml of water and evaporated. The title compound is obtained as a white solid from the residue by flash chromatography (SiO2 60F). Rf=0.10 (ethyl acetate-heptane 2:1), Rt=2.81 (gradient I).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-f8029e72a16342209f0f7ca8ecd22287
Source dataset
uspto-grants-2011_02
Patent number
US07879847B2

Reaction notes

Loading…