Chloroacetyl chloride → HCID 66781769, compound

Participants

Reaction Steps

A solution of 57.5 mmol of 2-amino-2-(4-methoxyphenyl)propan-1-ol in 190 ml of acetonitrile and 33 ml of methanol is cooled to −10° C., and 69 mmol of triethylamine and, dropwise over the course of 1 hour, 63.3 mmol of chloroacetyl chloride are successively added. The reaction mixture is warmed to room temperature and stirred for 16 hours. The mixture is evaporated, and the title compound is obtained as a colourless oil from the residue by flash chromatography (SiO2 60F). Rf=0.23 (ethyl acetate-heptane 2:1), Rt=2.88 (gradient I).

Provenance & Evidence