Lawesson's reagent → HCID 86632956, compound

HRID 1360155Notes

Reaction equation

HRID 1360155 reaction equation
[NH2:1][C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)([CH3:5])[CH2:3]O.COC1C=CC(P2(=S)SP(=S)(C3C=CC(OC)=CC=3)[S:23]2)=CC=1>C1(C)C=CC=CC=1>[NH2:1][C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)([CH3:5])[CH2:3][SH:23]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 61054422HCID 61054422, compound

Product 1

HCID 86632956HCID 86632956, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 1 mmol of 2-amino-2-(4-methoxyphenyl)propan-1-ol (Example 3k) and 0.5 mmol of 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's reagent) [19172-47-5] in 10 ml of toluene is heated to reflux for 2 hours. The reaction mixture is cooled to room temperature and evaporated. The title compound is identified from the residue on the basis of the Rf by flash chromatography (SiO2 60F).

Workup

  1. temperatureto reflux for 2 hours
  2. customevaporated

Sources & evidence

ORD record
ord-34837e680ad841068c065a633301c59a
Source dataset
uspto-grants-2011_02
Patent number
US07879847B2

Reaction notes

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