Hydrochloric Acid → (S)-(2-amino-1-methyl-ethoxy)-acetic acid ethyl ester hydrochloric acid salt

Participants

Reaction Steps

1.2 g (4.59 mmol) of (S)-(2-t-butoxycarbonylamino-1-methyl-ethoxy)-acetic acid ethyl ester was dissolved in 20 mL of ethyl acetate saturated with hydrochloric acid gas, followed by stirring at room temperature for 3 hours. The solvent was distilled off under reduced pressure, then the residue was purified by column chromatography to give 699 mg (3.49 mmol) of the title compound in a yield of 76%.

Provenance & Evidence