Cyanuric chloride → HCID 57928429, compound

Participants

Reaction Steps

4-(2-Oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)adamantan-1-carboxamide (70 mg) was suspended in N,N-dimethylformamide (1 ml), and 2,4,6-trichloro-1,3,5-triazine (37 mg) was added under ice cooling. The mixture was stirred at ambient temperature for 4 hours. To the reaction solution was added saturated aqueous sodium hydrogencarbonate, and the obtained solid was collected by filtration, washed with water and ethyl acetate to obtain 4-(2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)adamantan-1-carbonitrile (30 mg).

Provenance & Evidence