Trifluoroacetic acid → HCID 178522994, compound

Participants

Reaction Steps

To 3-(3,4-dimethoxybenzyl)-N-(4-fluorobenzyl)-7-{(5-hydroxyadamantan-2-yl)amino}-3H-imidazo[4,5-b]pyridine-6-carboxamide (170 mg) was added trifluoroacetic acid (1.7 ml), and the mixture was stirred at ambient temperature for overnight. The reaction solution was neutralized with saturated aqueous sodium hydrogencarbonate and extracted with ethyl acetate and tetrahydrofuran. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol) to obtain N-(4-fluorobenzyl)-7-{(5-hydroxyadamantan-2-yl)amino}-3H-imidazo[4,5-b]pyridine-6-carboxamide (31 mg).

Provenance & Evidence