Benzocaine → HCID 66788658, compound

HRID 1360283Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH3:26])=[C:6]([S:8]([N:11]2[C:15]3[CH:16]=[C:17]([C:22]([OH:24])=O)[CH:18]=[C:19]([O:20][CH3:21])[C:14]=3[O:13][CH2:12]2)(=[O:10])=[O:9])[CH:7]=1.[NH2:27][C:28]1[CH:38]=[CH:37][C:31]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[CH:30][CH:29]=1>>[CH2:35]([O:34][C:32](=[O:33])[C:31]1[CH:37]=[CH:38][C:28]([NH:27][C:22]([C:17]2[CH:18]=[C:19]([O:20][CH3:21])[C:14]3[O:13][CH2:12][N:11]([S:8]([C:6]4[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=4[O:25][CH3:26])(=[O:9])=[O:10])[C:15]=3[CH:16]=2)=[O:24])=[CH:29][CH:30]=1)[CH3:36]

Participants

Reactant 2

HCID 2337Benzocaine

HCID 66789430HCID 66789430, compound

Product 1

HCID 66788658HCID 66788658, compound

Procedure

Reaction of 3-(5-chloro-2-methoxy-benzenesulfonyl)-7-methoxy-2,3-dihydro-benzooxazole-5-carboxylic acid with ethyl 4-aminobenzoate in analogy with example 30, step 4 gave 4-{[3-(5-chloro-2-methoxy-benzenesulfonyl)-7-methoxy-2,3-dihydro-benzooxazole-5-carbonyl]-amino}-benzoic acid ethyl ester. White solid, MS (ISP)=547.2 (M+H)+.

Sources & evidence

ORD record: ord-2341c5b944bd43e1b5582f31e4f79e83
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879845B2

Reaction notes

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