4-(Dimethylamino)benzoyl chloride → HCID 66962337, compound

HRID 1360344Notes

Reaction equation

HRID 1360344 reaction equation
FC(F)(F)C(O)=O.[CH:8]1[C:16]2[C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[O:13][C:12]=2[C:11]([C:21]2[N:26]=[CH:25][N:24]=[C:23]([NH:27][C:28]3[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][CH:29]=3)[CH:22]=2)=[CH:10][CH:9]=1.[CH3:35][N:36]([CH3:46])[C:37]1[CH:45]=[CH:44][C:40]([C:41](Cl)=[O:42])=[CH:39][CH:38]=1>N1C=CC=CC=1>[CH:8]1[C:16]2[C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[O:13][C:12]=2[C:11]([C:21]2[N:26]=[CH:25][N:24]=[C:23]([NH:27][C:28]3[CH:29]=[CH:30][C:31]([NH:34][C:41](=[O:42])[C:40]4[CH:39]=[CH:38][C:37]([N:36]([CH3:35])[CH3:46])=[CH:45][CH:44]=4)=[CH:32][CH:33]=3)[CH:22]=2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 44007824-(Dimethylamino)benzoyl chlorideHCID 66962982HCID 66962982, compound2×

Product 1

HCID 66962337HCID 66962337, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of N-(6-dibenzofuran-4-yl-pyrimidin-4-yl)-benzene-1,4-diamine trifluoroacetate (compound A1) (500 mg, 1.1 mmol) in pyridine (10 mL) is added at 10° C. 4-dimethylaminobenzoyl chloride (288 mg, 1.21 mmol) portion wise. After 14 h at ambient temperature the mixture is evaporated and the crude product is purified by crystallization.

Workup

  1. customAfter 14 h at ambient temperature the mixture is evaporated
  2. customthe crude product is purified by crystallization

Sources & evidence

ORD record
ord-9ed3d61a89d24d718147034e33d50881
Source dataset
uspto-grants-2011_02
Patent number
US07879853B2

Reaction notes

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