HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Dimethylamino)benzoyl chloride → N-[3-(6-Dibenzofuran-4-yl-pyrimidin-4-ylamino)-phenyl]-4-dimethylamino-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Dimethylamino)benzoyl chloride | HCID 4400782 | — |
| Reactant | N-(6-dibenzofuran-4-yl-pyrimidinyl)-benzene-1,3-diamine trifluoroacetate | HCID 66962991 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-[3-(6-Dibenzofuran-4-yl-pyrimidin-4-ylamino)-phenyl]-4-dimethylamino-benzamide | HCID 66962968 | — |
Reaction Steps
To a solution of N-(6-dibenzofuran-4-yl-pyrimidinyl)-benzene-1,3-diamine trifluoroacetate (compound A2) (500 mg, 1.1 mmol) in pyridine (10 mL) is added at 10° C. 4-dimethylaminobenzoyl chloride (222 mg, 1.21 mmol) portion wise. After 2 days at ambient temperature the mixture is evaporated and the crude product is purified by crystallization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879853B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-bc39cfe3089c49c19a74eaccff7afc7d |
| Source note | uspto-grants-2011_02 |