HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-Nitroaniline → 2-[(6-Chloro)pyrimidin-4-ylamino]-1-methyl-4-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-Nitroaniline | HCID 7444 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 2-[(6-Chloro)pyrimidin-4-ylamino]-1-methyl-4-nitrobenzene | HCID 86061071 | — |
Reaction Steps
4,6-Dichloropyrimidine (5.37 g, 36.0 mmol) and 2-methyl-5-nitroaniline (5.48 g, 36.0 mmol) are heated in n-butanol (58 mL) with diisopropylethylamine (4.66 g, 36 mmol) for 3 days at 110° C. The mixture is evaporated and the product is purified by standard methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879853B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-d18eec901b3a4f67893cbd8b89dbbc6e |
| Source note | uspto-grants-2011_02 |