Chloroform → HCID 66963250, compound

HRID 1360355Notes

Reaction equation

HRID 1360355 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][N:4]=1)#[N:2].C(Cl)(Cl)[Cl:13].[H][H]>C(O)C.[Pd]>[ClH:13].[NH2:2][CH2:1][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][N:4]=1

Participants

6

Reactant 3

HCID 6212ChloroformHCID 27611086-Cyanopyridine-3-carboxylic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 66963250HCID 66963250, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6-Cyano-nicotinic acid (1 g, 6.7 mmol) is dissolved in ethanol (100 mL) and chloroform (2 mL) and hydrogenated at 3 bar hydrogen pressure for 5 h using palladium on charcoal as catalyst. After filtration of the catalyst the product is isolated by evaporation of the solvent.

Workup

  1. filtrationAfter filtration of the catalyst the product
  2. customis isolated by evaporation of the solvent

Sources & evidence

ORD record
ord-aa595d114325445fae5ec01e49da440b
Source dataset
uspto-grants-2011_02
Patent number
US07879853B2

Reaction notes

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