HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → Methyl 3-(cyanomethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | Methyl 3-(bromomethyl)benzoate | HCID 517981 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 3-(cyanomethyl)benzoate | HCID 10821136 | — |
Reaction Steps
To methyl 3-bromomethyl-benzoate (25.28 g, 0.11 mol) in acetonitrile (230 mL) is added potassium cyanide (14.3 g, 0.22 mmol) and 18-crown-6 (1.00 g, 2.6 mmol) and the mixture is heated to reflux for 24 h. After filtration, the crude product is transferred to the next step without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879853B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-f207549584a6427fa625fe3084742a23 |
| Source note | uspto-grants-2011_02 |