HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine → N1-(2-phenylethyl)-N2-[4-(trifluoromethyl)phenyl]-D-valinamide trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | N-[4-(trifluoromethyl)phenyl]-D-valine | HCID 13388455 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N1-(2-phenylethyl)-N2-[4-(trifluoromethyl)phenyl]-D-valinamide trifluoroacetate | HCID 86611433 | 46.8% |
Reaction Steps
N-[4-(Trifluoromethyl)phenyl]-D-valine (20 mg, 0.077 mmol) obtained in step 1, phenethylamine (11 μl, 0.087 mmol), 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (18 mg, 0.12 mmol) and 1-hydroxybenzotriazole monohydrate (22 mg, 0.12 mmol) were mixed in methylene chloride (3 mL), and the mixture was stirred overnight at room temperature. The solvent was evaporated and, using the following purification step A, the title compound (8.48 mg, 0.018 mmol, 23%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879863B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-b75bd82ac6fa4fb8aca1222070f6a819 |
| Source note | uspto-grants-2011_02 |