HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1360392Generated: October 27, 2026
Phenol → N-[(1R)-2-methyl-1-(phenoxymethyl)propyl]-4-(trifluoromethyl)aniline
https://huagongshe.com/reaction/1360392
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | (2R)-3-methyl-2-{[4-(trifluoromethyl)phenyl]amino}butan-1-ol | HCID 66968920 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[(1R)-2-methyl-1-(phenoxymethyl)propyl]-4-(trifluoromethyl)aniline | HCID 66969217 | 3.4% |
Reaction Steps
(2R)-3-Methyl-2-{[4-(trifluoromethyl)phenyl]amino}butan-1-ol (50 mg, 0.201 mmol), which is the compound obtained in Step 1 of Example 2, phenol (19 mg) and triphenylphosphine (63 mg) were dissolved in tetrahydrofuran (1 mL), and after cooling to 0° C., diisopropyl azodicarboxylate (0.13 mL) was added dropwise. The mixture was stirred overnight at 50° C. and purified by purification step A to give the title compound (2.18 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07879863B2 |
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| Source dataset | uspto-grants-2011_02 |
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| ORD ID | ord-5664b5bc77c349a9aa7539638b57d93d |
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| Source note | uspto-grants-2011_02 |
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