Benzyl Bromide → N-{(1R)-1-[(benzyloxy)methyl]-2-methylpropyl}-4-(trifluoromethyl)aniline

Participants

Reaction Conditions

Reaction Steps

Sodium hydride (10 mg) and (2R)-3-methyl-2-{[4-(trifluoromethyl)phenyl]amino}butan-1-ol (30 mg), which is the compound obtained in Step 1 of Example 2, were dissolved in dimethylformamide (1 mL), and then benzyl bromide (0.052 mL) was added. The mixture was stirred at 50° C. for 3 hrs, and the title compound (37.5 mg) was obtained by purification step A.

Provenance & Evidence