Phenethyl bromide → N-{(1R)-2-methyl-1-[(2-phenylethoxy)methyl]propyl}-4-(trifluoromethyl)aniline

Participants

Reaction Conditions

Reaction Steps

(2R)-3-Methyl-2-{[4-(trifluoromethyl)phenyl]amino}butan-1-ol (50 mg, 0.201 mmol), which is the compound obtained in Step 1 of Example 2, phenethylbromide (0.22 mL, 2.01 mmol) and tetrabutylammonium hydrogensulfate (catalytic amount) were added to a mixed solvent of benzene(1 mL) and 50% aqueous sodium hydroxide solution (1 mL), and the mixture was stirred at 50° C. for 2 days. After work-up according to a conventional method, the mixture was purified by purification step A to give the title compound (4.76 mg).

Provenance & Evidence