Hydrochloric Acid → HCID 16659952, compound

Participants

Reaction Steps

An excess of a solution of HCl (4N in 1,4-dioxane) was added to a solution of N-[2-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-1-pyridin-3-ylethyl]-N-hydroxyformamide (55 mg, 80% purity) in 1,4-dioxane. A solid precipitated out. The supernatant was removed by decantation, then the solid was washed by decantation with Et2O (2×) and dried under reduced pressure to give the title compound (11) as an off-white powder (25 mg, 40% yield). HPLC, Rt: 1.9 min (purity: 83.0%). LC/MS, M+(ESI): 362.3, M−(ESI): 360.3.

Provenance & Evidence