Cuminaldehyde → HCID 24786789, compound

Participants

Reaction Steps

A mixture of 4-isopropyl benzaldehyde (25 g, 183 mmol) and aminoacetaldehyde dimethylacetal (28.9 g, 275 mmol) in toluene (250 ml) was refluxed with azeotropic removal of water for 13 hours. The solvent was removed under vacuum to afford the titled compound as viscous oil (36 g, 83%). TLC-Chloroform/methanol: (95/5): Rf=0.75. 1H-NMR (CDCl3, 400 MHz) δ 1.28 (6H, d), 2.95 (1H, m), 3.44 (6H, s), 3.78 (2H, d), 4.68 (1H, t), 7.28 (2H, d), 7.68 (2H, d), 8.27 (1H, s).

Provenance & Evidence