Sodium borohydride → HCID 57855474, compound

Participants

Reaction Steps

A suspension of 1-[(7-chloro-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl]-3-phenoxyacetone (468 mg, 1.23 mmol) was prepared in MeOH (15 ml), then NaBH4 (77 mg, 1.85 mmol) was added portionwise. The resulting mixture was stirred at RT for 1 h00. The reaction mixture was concentrated under reduced pressure, then diluted with EtOAc (30 ml) and washed with a 1N aqueous solution of HCl (15 ml) and a saturated aqueous solution of NaHCO3 (15 ml). The aqueous layers were extracted with EtOAc (30 ml). The organic layers were combined, dried (MgSO4) and the solvent was removed under reduced pressure. After purification by crystallization in EtOAc/pentane, the title compound was obtained as a white powder (415 mg, 88%). HPLC, Rt: 4.5 min (purity: 99.2%). LC/MS, M+(ESI): 382.2.

Provenance & Evidence