Sodium Carbonate → HCID 15950606, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-chloro-1-(2,6-dichlorophenyl)-2H-quinolizin-2-one (Example 1, 54 mg) in DME was added 2-chlorophenylboronic acid (31 mg), palladium acetate (3.5 mg), triphenylphosphine (8 mg) and 2N sodium carbonate (0.32 mL). The mixture was heated to 80° C. for 12 hrs, then cooled to room temperature, and diluted with ethyl acetate/saturated aqueous sodium bicarbonate. The organic layers were dried over magnesium sulfate and concentrated. The residue was purified by silica gel (methylene chloride/acetone=2/1) and recrystallized from methylene chloride/acetone/hexanes to give title compound as a yellowish solid (28 mg).

Provenance & Evidence