Sodium hydride → HCID 16064455, compound

Participants

Reaction Steps

To oil free sodium hydride (24 mg) suspended in DMF was added cyclopropylmethanol (0.08 mL) at room temperature and stirred for ½ hr. To this mixture was added 6-chloro-1-(2,6-dichlorophenyl)-2H-quinolizin-2-one (Example 1, 15 mg) and stirred for approximately 1-3 hours. The mixture was diluted with ethyl acetate/water. The organic layers were washed with water (3×), brine, and dried over magnesium sulfate. Upon evaporation, the residue was purified by silica gel (methylene chloride/acetone=3/1) to give title compound (15 mg).

Provenance & Evidence