Boron tribromide → HCID 178516338, compound

Participants

Reaction Steps

To a solution of 6-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-8-methoxy-2H-quinolizin-2-one (Example 14, 40 mg) in methylene chloride was added boron tribromide (0.06 mL) at −78° C. The mixture was warmed to room temperature and stirred for 12 h. After quenching with 2N HCl, the mixture was extracted with methylene chloride, washed with brine, dried over magnesium sulfate and concentrated. The residue was purified by silica gel (methylene chloride/methano-=7/1) to give title compound (25 mg).

Provenance & Evidence