反应详情

A solution of 8-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-6-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2H-quinolizin-2-one hydrochloride (Example 19, 24 mg) in methanol/ethyl acetate=1/5 was added platinum oxide (9 mg). The solution was hydrogenated under hydrogen (1 atm) for 1 h. The mixture was filtered though celite and concentrated. The residue was purified by silica gel (methylene chloride/methanol/2N ammonia=10/1/0.2) to give the title compound.

1. filtrationThe mixture was filtered though celite and
2. concentrationconcentrated
3. customThe residue was purified by silica gel (methylene chloride/methanol/2N ammonia=10/1/0.2)