反应详情

To a solution of 4-fluoro-3-methylbenzonitrile (15.0 g, 111 mmol), in CCl4 (600 mL) was added N-bromosuccinimide (23.7 g, 133 mmol), and benzoyl peroxide (5.38 g, 22.2 mol). The mixture was irradiated with a sunlamp (250 W) to create a gentle reflux. After 0.5 hours of exposure the reaction was complete by TLC. The reaction mixture was cooled and filtered through celite. The filtrate was condensed in vacou to yield brown oil. The crude residue was purified via silica gel column chromatography (hexanes/ethyl acetate) to yield 17.7 g of the desired product.

1. customThe mixture was irradiated with a sunlamp (250 W)
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered through celite
4. customcondensed in vacou
5. customto yield brown oil
6. customThe crude residue was purified via silica gel column chromatography (hexanes/ethyl acetate)