反应详情

温度

0 °C

To a solution of (4-bromo-2,6-difluorophenyl)methanol (24.8 g, 112.1 mmol) in CH2Cl2 (400 mL) was added TEA (22.68 g, 224.28 mmol) and methylsulfonyl chloride (12.84 mL, 156.9 mmol) at 0° C. The reaction was stirred at 0° C. for 1 h, quenched with aqueous NH4Cl, and diluted with EtOAc. The organic layer was washed with 1N HCl (2×), H2O, brine, dried over MgSO4, and condensed to give the desired compound.

1. customquenched with aqueous NH4Cl
2. additiondiluted with EtOAc
3. washThe organic layer was washed with 1N HCl (2×), H2O, brine
4. dry with materialdried over MgSO4, and condensed