Stannane, tributyl(1-ethoxyethenyl)- → HCID 16065044, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(4-bromo-2,6-difluorophenyl)-6-(2,4-difluorophenyl)-2H-quinolizin-2-one (30 mg, 0.067 mmol) in toluene (1.4 mL) was added tributyl(1-ethoxyvinyl)stannane and tetrakis(triphenylphosphine)palladium (7.74 mg, 0.007 mmol) and heated to 90° C. for 1½ h. The reaction was cooled, filtered through celite, and diluted with THF. The mixture was added 2N HCl and stirred for 20 min to complete the reaction. The crude mixture was diluted with H2O and EtOAc. The organic layer was washed with H2O, brine, dried over MgSO4, and condensed. The crude residue was purified via silica gel chromatography (hexanes/ethyl acetate) to give the title compound (7.9 mg).

Provenance & Evidence