Methyl N-(triethylammoniosulfonyl)carbamate → HCID 25235717, compound

Participants

Reaction Steps

To a 20 mL microwave vial was added 0.500 g (1.09 mmol) of 4-Chloro-benzoic acid N′-[2-(2,6-dichloro-phenyl)-3H-benzoimidazole-5-carbonyl]-hydrazide, 13 mL of THF, and 0.5187 g (2.18 mmol) of Burgess Reagent. The suspension was placed in the microwave at 150° C. for 20 min. The crude solution was concentrated and the residue was purified by silica gel column chromatography (ACN/DCM, 1:9 to 6:4) to give of the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.62-7.67 (m, 1H) 7.68-7.74 (m, 4.5H) 7.78-7.81 (m, 0.6H) 7.94 (d, J=8.46 Hz, 0.5H) 8.02-8.10 (m, 1H) 8.17-8.22 (m, 2H) 8.33 (d, J=1.01 Hz, 0.4H) 8.49-8.52 (m, 0.6H) 13.36 (d, J=10.36 Hz, 1H). MS (m/z) 442.9 M (+1), tR=1.49, Meth 10

Provenance & Evidence