Methyl N-(triethylammoniosulfonyl)carbamate → HCID 25235813, compound

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Reaction Steps

To a 5 mL microwave vial was added 0.2225 g (0.537 mmol) of 4-Methoxy-benzoic acid N′-[2-(2,6-dimethyl-phenyl)-3H-benzoimidazole-5-carbonyl]-hydrazide, 4 mL of THF, and 0.2558 g (1.07 mmol) of burgess reagent. The suspension was placed in the microwave at 150° C. for 15 min. The crude solution was concentrated and the residue was purified by silica gel column chromatography (EtOAc/DCM, 1:9 to 6:4) to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.28 (s, 6H) 4.02 (s, 3H) 7.35 (dd, J=15.73, 8.27 Hz, 4H) 7.50 (t, J=7.64 Hz, 1H) 7.87 (d, J=8.34 Hz, 0.5H) 8.04 (d, J=8.46 Hz, 0.5H) 8.15 (dd, J=12.19, 8.65 Hz, 1H) 8.24-8.29 (m, 2H) 8.38 (s, 0.4H) 8.60 (s, 0.5H) 13.15 (d, J=14.27 Hz, 1H). MS (m/z) 397.2 M (+1), tR=1.48, Meth 10

Provenance & Evidence