Hydrochloric Acid → 2-(2,6-Dichloro-phenyl)-3H-benzoimidazole-5-carboxylic acid

Participants

Reaction Steps

To a solution of 2-(2,6-dichlorophenyl)-3H-benzoimidazole-5-carboxylic acid methyl ester (5.8 g) in 40 mL of MeOH/THF (1:1) was added 1N NaOH (20 mL). The mixture was stirred at RT for 18 h then 1N HCl was added until pH 3. The resulting precipitate was filtered, washed with water and dried under reduced pressure to give the title compound.

Provenance & Evidence