Methyl N-(triethylammoniosulfonyl)carbamate → HCID 66966785, compound

Participants

Reaction Steps

To a 5 mL microwave vial was added 0.2010 g (0.369 mmol) of (4-{6-[N′-(4-Chloro-benzoyl)-hydrazinocarbonyl]-1H-benzoimidazol-2-yl}-3,5-dimethyl-phenoxy)-acetic acid methyl ester, 5 mL of THF, and 0.1890 g (0.793 mmol) of burgess reagent. The suspension was placed in the microwave at 150° C. for 20 min. The brownish solution was concentrated and the residue was purified by silica gel (ACN/DCM, 1:9 to 5:5) to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.10 (s, 6H) 3.72 (s, 4H) 4.86 (s, 2H) 6.81 (s, 2H) 7.68-7.74 (m, 2.5H) 7.87 (d, J=8.46 Hz, 0.5H) 7.97-8.04 (m, 1H) 8.15-8.24 (m, 2.5H) 8.45 (s, 0.5H) 12.93 (d, J=15.66 Hz, 1H). MS (m/z) 489.1 M (+1), tR=1.40, Meth 10

Provenance & Evidence