反应详情

A mixture of the above 2,2,2-trifluoro-N-(4-formyl-3,5-dimethylphenyl)-acetamide in MeOH (30 mL) and 1 N NaOH (30 mL) was stirred at RT overnight. To the suspension was added 100 mL of water and the solid was filtered, washed with water, and dried. The aqueous layer was extracted with EtOAc and the organic layer was washed with water, brine, dried with MgSO4, and filtered. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (heptane/EtOAc=4:1) to give the title compound. MS: m/z 150 (M+1).

1. filtrationthe solid was filtered
2. washwashed with water
3. customdried
4. extractionThe aqueous layer was extracted with EtOAc
5. washthe organic layer was washed with water, brine
6. dry with materialdried with MgSO4
7. filtrationfiltered
8. customThe solvent was removed under reduced pressure
9. customthe residue was purified by flash chromatography (heptane/EtOAc=4:1)