3-(4-Formyl-3,5-dimethylphenyl)-acrylic acid methyl ester → Methyl 3-(3,5-dimethyl-4-formylphenyl)propionate

Participants

Reaction Steps

A mixture of 3-(4-formyl-3,5-dimethylphenyl)-acrylic acid methyl ester (900 mg, 4.1 mmol) and 10% Pd/C (90 mg) in CH2Cl2 (20 mL) was hydrogenated at one atm overnight. The catalyst was filtered through Celite and washed with CH2Cl2. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (heptane/EtOAc=5:1) to give the title compound. MS: m/z 221 (M+1).

Provenance & Evidence