HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178500174, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Reactant | 3-(4-{6-[5-(3-Chlorophenylamino)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid | HCID 25210591 | — |
| Reactant | Methyl 3-(4-formyl-3,5-dimethylphenyl)-2,2-dimethylpropanoate | HCID 86632822 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178500174 | HCID 178500174 | — |
Reaction Steps
Oxone (420 mg, 0.683 mmol) was added to a mixture of 3-(4-formyl-3,5-dimethyl-phenyl)-2,2-dimethyl-propionic acid methyl ester (250 mg, 1.00 mmol) and 4-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine (prepared as described in Example 1-59, 300 mg, 1.06 mmol) in DMF (8 mL) and water (0.8 mL), and the mixture was stirred at room temperature for 18 h. The mixture was partitioned between EtOAc and water. The EtOAc extract was washed with brine, dried over Na2SO4, concentrated and chromatographed to give the title compound. m/z 511.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879850B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-cb1966aa095c43a7b760958a6abbfdb6 |
| Source note | uspto-grants-2011_02 |