4-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine → 3-(3,5-Dichloro-4-{6-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-phenyl)-propionic acid tert-butyl ester

Participants

Reaction Steps

To a 20 ml scint. vial was added 0.3783 g (1.32 mmol) 4-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine, 0.4000 g (1.32 mmol) of 3-(3,5-Dichloro-4-formyl-phenyl)-propionic acid tert-butyl ester (step A), and 6 mL of DMSO. To this dark brown solution was added 0.0321 g (0.198 mmol) of FeCl3. Allowed to stir open to air for 72 h. Extracted with EtOAc, and washed with water, brine and dried with Na2SO4. Purified on silica gel (ACN/DCM, 1:9 to 4:6) to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.39 (9H) 2.64 (t, J=7.33 Hz, 2H) 2.92 (t, J=7.26 Hz, 2H) 7.60 (s, 2H) 7.72 (d, 2H) 7.78 (d, J=8.59 Hz, 0.5H) 7.92 (d, J=8.46 Hz, 0.5H) 8.00-8.09 (m, 1H) 8.17-8.22 (m, 2H) 8.31 (s, 0.5H) 8.50 (s, 0.5H) 13.32 (d, J=11.24 Hz, 1H). MS (m/z) 571.1 M (+1), tR=1.59, Meth 10

Provenance & Evidence